Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945358 | 0.84 | SLC2A1 (0.46) | AKT1AKT2NPC1RAB9AFAAH | |
| SCHEMBL6853531 | 0.81 | DRD2 (0.50) | AKT1AKT2ALDH1A1KDM4E | |
| SCHEMBL6853072 | 0.79 | ADORA2A (0.53) | ALDH1A1PKMFAAH | |
| SCHEMBL6857830 | 0.79 | TACR2 (0.55) | TSHRLMNA | |
| SCHEMBL5442168 | 0.78 | PDE10A (0.43) | AKT1ALDH1A1NPC1RAB9ATDP1 | |
| SCHEMBL6854970 | 0.78 | KMT2A (0.50) | AKT1ALDH1A1KCNH2NPC1RAB9A | |
| SCHEMBL6853186 | 0.78 | LDHA (0.49) | AKT1KCNH2TDP1KDM4EFAAH | |
| SCHEMBL6853013 | 0.77 | HRH3 (0.48) | ALDH1A1NPC1RAB9ATDP1KDM4E | |
| SCHEMBL6851652 | 0.76 | TACR3 (0.50) | AKT1ALDH1A1HSD17B10KCNH2KDM4E | |
| SCHEMBL6853374 | 0.76 | TACR3 (0.50) | ALDH1A1KCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |