Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854970 | 0.90 | KMT2A (0.50) | DRD4DRD3SIGMAR1FAAHDRD2 | |
| SCHEMBL6853013 | 0.83 | HRH3 (0.48) | FAAHKDM4EALDH1A1KMT2ACYP2C9 | |
| SCHEMBL6848935 | 0.80 | SLC2A1 (0.44) | FAAHKDM4EALDH1A1HTT | |
| SCHEMBL6848678 | 0.80 | TACR2 (0.53) | FAAHHTT | |
| SCHEMBL5908682 | 0.80 | FAAH (0.42) | FAAHKDM4EALDH1A1KMT2AHTT | |
| SCHEMBL5442168 | 0.80 | PDE10A (0.43) | FAAHKDM4EALDH1A1KMT2A | |
| SCHEMBL6853643 | 0.79 | TSHR (0.55) | DRD4DRD3DRD2HTR1AKDM4E | |
| SCHEMBL6853186 | 0.79 | LDHA (0.49) | FAAHKDM4EKMT2A | |
| SCHEMBL5945358 | 0.79 | SLC2A1 (0.46) | HTR2BFAAH | |
| SCHEMBL6851670 | 0.78 | PDE10A (0.43) | FAAHKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |