Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | DRD4 | P21917 | 7/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 3/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945358 | 0.86 | SLC2A1 (0.46) | AKT1AKT2AKT3HTR2B | |
| SCHEMBL6854970 | 0.82 | KMT2A (0.50) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL6851740 | 0.81 | AKT1 (0.48) | KDM4EALDH1A1AKT1AKT2 | |
| SCHEMBL6853013 | 0.81 | HRH3 (0.48) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL6851652 | 0.80 | TACR3 (0.50) | KMT2AKDM4EALDH1A1AKT1 | |
| SCHEMBL6853374 | 0.80 | TACR3 (0.50) | DRD4DRD3MEN1KMT2AKDM4E | |
| SCHEMBL5442168 | 0.80 | PDE10A (0.43) | MEN1KMT2AKDM4EALDH1A1AKT1 | |
| SCHEMBL28806851 | 0.78 | DHFR (0.47) | DRD2DRD4DRD3GRM2KDM4E | |
| SCHEMBL6853077 | 0.78 | HTR2B (0.49) | DRD2DRD4DRD3GRM2KMT2A | |
| SCHEMBL6848935 | 0.78 | SLC2A1 (0.44) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |