Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854970 | 0.83 | KMT2A (0.50) | FAAHPDE10AKCNH2KDM4EMEN1 | |
| SCHEMBL6853013 | 0.82 | HRH3 (0.48) | FAAHPIK3CDPDE10ABACE1TDP1 | |
| SCHEMBL5442168 | 0.81 | PDE10A (0.43) | FAAHPIK3CDPDE10AADORA2AADORA1 | |
| SCHEMBL5945358 | 0.80 | SLC2A1 (0.46) | FAAHPIK3CDPDE10ATACR3PIK3CG | |
| SCHEMBL6853072 | 0.80 | ADORA2A (0.53) | FAAHADORA2AADORA1TACR3MEN1 | |
| SCHEMBL6848935 | 0.79 | SLC2A1 (0.44) | FAAHPIK3CDPDE10ABACE1TACR3 | |
| SCHEMBL6853077 | 0.79 | HTR2B (0.49) | FAAHKDM4EKMT2A | |
| SCHEMBL5908682 | 0.79 | FAAH (0.42) | FAAHPIK3CDPDE10ABACE1TDP1 | |
| SCHEMBL6848678 | 0.79 | TACR2 (0.53) | FAAHPIK3CDPDE10ABACE1TACR3 | |
| SCHEMBL6853643 | 0.78 | TSHR (0.55) | KDM4EMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |