Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 8/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853309 | 0.88 | DRD4 (0.52) | TSHRALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL6854970 | 0.83 | KMT2A (0.50) | ALDH1A1DRD4DRD2DRD3NPC1 | |
| SCHEMBL6853013 | 0.82 | HRH3 (0.48) | ALDH1A1POLBNPC1RAB9AKMT2A | |
| SCHEMBL6848935 | 0.79 | SLC2A1 (0.44) | ALDH1A1HTTKDM4E | |
| SCHEMBL5908682 | 0.79 | FAAH (0.42) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6848678 | 0.79 | TACR2 (0.53) | LMNAHTTNPSR1 | |
| SCHEMBL6853077 | 0.79 | HTR2B (0.49) | ALDH1A1DRD4DRD2DRD3HTR1A | |
| SCHEMBL5442168 | 0.79 | PDE10A (0.43) | ALDH1A1POLBNPC1RAB9AMEN1 | |
| SCHEMBL6853186 | 0.78 | LDHA (0.49) | MEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL5945358 | 0.78 | SLC2A1 (0.46) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |