Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.47 |
| ▸ | MMP13 | P45452 | 12/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.47 |
| ▸ | MMP1 | P03956 | 10/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708418 | 0.77 | ADAM17 (0.59) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL8424025 | 0.70 | ALDH1A1 (0.42) | — | |
| SCHEMBL8424066 | 0.69 | HPGD (0.43) | ADAM17MMP1 | |
| SCHEMBL6753835 | 0.69 | ADAM17 (0.61) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL8424170 | 0.68 | ALDH1A1 (0.49) | — | |
| SCHEMBL8425464 | 0.68 | S1PR5 (0.44) | — | |
| SCHEMBL8423721 | 0.68 | ALDH1A1 (0.39) | — | |
| SCHEMBL3941951 | 0.67 | ADAM17 (0.54) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6268743 | 0.67 | ADAM17 (0.49) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL8423588 | 0.66 | ALDH1A1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229924-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors | WYETH | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229924-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors | MMP17, MMP1, MMP9 | ADAM17 12/4885MMP13 16/4885MMP9 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.