SCHEMBL6858347

SCHEMBL6858347

CCCCCc1c(C)c(C)nc2c(F)cc(C(C)(C)C)cc12

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 1/20 0.34
GHSR Q92847 1/20 0.34
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
GCGR P47871 4/20 0.32
TLR8 Q9NR97 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7039428 0.96 HTR1D (0.35) HTR1D
SCHEMBL1278420 0.77 RXRA (0.37) MAPT
SCHEMBL6858344 0.76 HTR7 (0.34) MAPTHTT
SCHEMBL1613863 0.74 MAPT (0.36) MAPTNPSR1
SCHEMBL6858389 0.74 GABRA1 (0.34)
SCHEMBL6855230 0.74 FASN (0.34)
SCHEMBL6857733 0.73 ESR1 (0.40) MAPT
SCHEMBL1278913 0.73 CD69 (0.35)
SCHEMBL6858360 0.72 DHODH (0.34) HTR1D
SCHEMBL6851310 0.70 ADORA3 (0.39) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6787557-B2 2,3-dimethyl-6-t-butyl-8-fluoro-4-hydroxyquinoline or ester derivatives; plant fungicides; Pyricularia MEIJI SEIKA KAISHA, LTD. (JP) 2004-09-07 US claimed
US-6787557-B2 2,3-dimethyl-6-t-butyl-8-fluoro-4-hydroxyquinoline or ester derivatives; plant fungicides; Pyricularia MEIJI SEIKA KAISHA, LTD. (JP) 2004-09-07 US disclosed
US-20030176459-A1 Rice blast control agents MEIJI SEIKA PHARMA CO., LTD. (JP) 2003-09-18 US disclosed
EP-1291344-A1 RICE BLAST CONTROL AGENTS MEIJI SEIKA KAISHA LTD. (JP) 2003-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030176459-A1 Rice blast control agents CNOT1, OSR1, RER1 HTR1D 2009/4885GHSR 654/4885MAPT 3187/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.