SCHEMBL6858360

SCHEMBL6858360

CCC(=O)c1c(C)c(C)nc2c(F)cc(C(C)(C)C)cc12

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.34
PTGFR P43088 1/20 0.31
MEN1 O00255 1/20 0.31
CYP3A4 P08684 1/20 0.31
PTGS1 P23219 1/20 0.31
DRD3 P35462 1/20 0.31
KMT2A Q03164 1/20 0.31
HTR1D P28221 1/20 0.30
FYN P06241 1/20 0.30
PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6855230 0.91 FASN (0.34) DHODHPTGFR
SCHEMBL6858344 0.88 HTR7 (0.34) DHODHMEN1PTGS1KMT2APDE10A
SCHEMBL6855568 0.86 DHODH (0.32) DHODHPTGFR
SCHEMBL29979517 0.85 DHODH (0.36) DHODHPTGFRMEN1KMT2APDE10A
SCHEMBL346736 0.85 DHODH (0.36) DHODHPTGFRMEN1KMT2APDE10A
SCHEMBL6858350 0.85 ALDH1A1 (0.40) DHODHMEN1KMT2A
SCHEMBL6857752 0.84 DHODH (0.31) DHODH
Acetic Acid SCHEMBL28595977 0.83 DHODH (0.44) DHODHPTGFRPDE10A
SCHEMBL6851310 0.82 ADORA3 (0.39)
SCHEMBL6856342 0.82 DHODH (0.38) DHODHPTGFRMEN1CYP3A4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6787557-B2 2,3-dimethyl-6-t-butyl-8-fluoro-4-hydroxyquinoline or ester derivatives; plant fungicides; Pyricularia MEIJI SEIKA KAISHA, LTD. (JP) 2004-09-07 US claimed
US-6787557-B2 2,3-dimethyl-6-t-butyl-8-fluoro-4-hydroxyquinoline or ester derivatives; plant fungicides; Pyricularia MEIJI SEIKA KAISHA, LTD. (JP) 2004-09-07 US disclosed
US-20030176459-A1 Rice blast control agents MEIJI SEIKA PHARMA CO., LTD. (JP) 2003-09-18 US disclosed
EP-1291344-A1 RICE BLAST CONTROL AGENTS MEIJI SEIKA KAISHA LTD. (JP) 2003-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030176459-A1 Rice blast control agents CNOT1, OSR1, RER1 DHODH 3180/4885PTGFR 4795/4885MEN1 1235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.