Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.37 |
| ▸ | MMP2 | P08253 | 9/20 | 0.36 |
| ▸ | MMP9 | P14780 | 8/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 4/20 | 0.34 |
| ▸ | MMP13 | P45452 | 4/20 | 0.34 |
| ▸ | MMP14 | P50281 | 3/20 | 0.34 |
| ▸ | MMP16 | P51512 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864813 | 0.92 | MMP1 (0.38) | MMP1MMP2MMP9CA2CA9 | |
| SCHEMBL6863772 | 0.85 | ALDH1A1 (0.35) | MMP1MMP2MMP9CA2CA9 | |
| SCHEMBL6864366 | 0.84 | ALDH1A1 (0.34) | MMP1MMP2MMP9CA2CA9 | |
| SCHEMBL6865493 | 0.82 | MMP3 (0.42) | MMP1MMP2MMP9KMT2AMMP13 | |
| SCHEMBL6864397 | 0.81 | MMP1 (0.44) | MMP1MMP2MMP9CA2CA9 | |
| SCHEMBL6864101 | 0.78 | AHCY (0.38) | MMP3 | |
| SCHEMBL328649 | 0.73 | MMP1 (0.44) | MMP1MMP2MMP9CA2CA9 | |
| SCHEMBL6864164 | 0.72 | MMP2 (0.33) | MMP1MMP2MMP9KMT2AMMP8 | |
| SCHEMBL6863163 | 0.72 | MMP1 (0.44) | MMP1MMP2MMP9CA2CA9 | |
| SCHEMBL328548 | 0.72 | DAGLA (0.37) | CA9KMT2AALDH1A1L3MBTL1BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |