Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865493 | 0.77 | MMP3 (0.42) | MEN1KMT2AMMP3BMP1ALDH1A1 | |
| SCHEMBL6864366 | 0.77 | ALDH1A1 (0.34) | MMP3ALDH1A1 | |
| SCHEMBL6865718 | 0.76 | MMP3 (0.58) | MEN1KMT2AMMP3BMP1ALDH1A1 | |
| SCHEMBL328554 | 0.75 | MMP3 (0.48) | MEN1KMT2AMMP3BMP1ALDH1A1 | |
| SCHEMBL6864106 | 0.75 | MMP3 (0.50) | MEN1KMT2AMMP3BMP1ALDH1A1 | |
| SCHEMBL6864101 | 0.74 | AHCY (0.38) | MMP3KDM4E | |
| SCHEMBL6864813 | 0.73 | MMP1 (0.38) | KMT2AMMP3BMP1ALDH1A1 | |
| SCHEMBL6863772 | 0.73 | ALDH1A1 (0.35) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6864164 | 0.73 | MMP2 (0.33) | MEN1KMT2AMMP3 | |
| SCHEMBL328403 | 0.73 | MEN1 (0.40) | MEN1KMT2AMMP3FKBP1ABMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |