SCHEMBL6864978

SCHEMBL6864978

N#Cc1ccc(C#Cc2ccc(O)c(F)c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
P4HB P07237 3/20 0.50
CA12 O43570 1/20 0.45
CA2 P00918 1/20 0.45
CA3 P07451 1/20 0.45
CA6 P23280 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
CYP19A1 P11511 3/20 0.45
AR P10275 1/20 0.44
MMP3 P08254 1/20 0.41
ESR1 P03372 6/20 0.40
ESR2 Q92731 6/20 0.40
HNF4A P41235 1/20 0.40
KIF11 P52732 1/20 0.39
FFAR1 O14842 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29826346 0.88 P4HB (0.51) P4HBCA12CA2CA3CA6
SCHEMBL200168 0.88 P4HB (0.51) P4HBCA12CA2CA3CA6
SCHEMBL7710176 0.88 HNF4A (0.42) P4HBCA3CA6CA9CA14
SCHEMBL9063141 0.81 KIF11 (0.59) P4HBCA12CA2CA3CA6
SCHEMBL2786052 0.81 KIF11 (0.59) P4HBCA12CA2CA3CA6
4-Cyanophenol SCHEMBL28162196 0.78 CA3 (0.57) P4HBCA12CA2CA3CA6
SCHEMBL15014228 0.77 APP (0.59) CA12CA2CA9
SCHEMBL8050262 0.75 P4HB (0.63) P4HBCA2CYP19A1ESR1ESR2
SCHEMBL6864959 0.74 TRPV4 (0.47) CA12CA2CA3CA6CA9
Propionic Acid SCHEMBL10764681 0.74 P4HB (0.48) P4HBCYP19A1ARFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6805920-B2 For producing liquid crystal display (LCD) NITTO DENKO CORPORATION (JP) 2004-10-19 US disclosed
US-20030072893-A1 Polymerizable liquid crystal compound and optical film NITTO DENKO CORPORATION (JP) 2003-04-17 US disclosed