Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.47 |
| ▸ | WNT1 | P04628 | 5/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868095 | 0.85 | KDM4E (0.53) | KDM4EHTTADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6867024 | 0.81 | F12 (0.41) | ADORA2ASMN1; SMN2F12 | |
| SCHEMBL6870751 | 0.80 | ADORA2A (0.41) | KDM4EHTTMAP4K4ADORA2AABL1 | |
| SCHEMBL6867215 | 0.79 | PLAU (0.47) | ABL1SMN1; SMN2 | |
| SCHEMBL6871922 | 0.79 | CYP19A1 (0.54) | KDM4EABL1ALDH1A1F12 | |
| SCHEMBL6869838 | 0.78 | ADORA2A (0.43) | KDM4EHTTADORA2AALDH1A1 | |
| SCHEMBL6868478 | 0.78 | ADORA2A (0.64) | GRM5KDM4EHTTADORA2AALDH1A1 | |
| SCHEMBL6863748 | 0.76 | ADORA2A (0.64) | KDM4EHTTADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6871512 | 0.76 | KMT2A (0.49) | ADORA2AALDH1A1F12 | |
| SCHEMBL6868261 | 0.75 | NPC1 (0.48) | KDM4EHTTADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |