Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305864 | 0.81 | PARP1 (0.44) | HTR1AADRB2ADRB1CHRM2KDM4E | |
| SCHEMBL6875889 | 0.79 | TUBB4A (0.44) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5305861 | 0.78 | HPGD (0.45) | HTR1AADRB2ADRB1CHRM2KDM4E | |
| SCHEMBL7496719 | 0.76 | KDM4E (0.54) | KDM4ETP53HPGDKMT2AHSD17B10 | |
| SCHEMBL6865989 | 0.76 | ACHE (0.41) | CHRM2CYP3A4CNR1SLC6A2SLC6A3 | |
| SCHEMBL25920617 | 0.74 | LMNA (0.56) | CHRM2MEN1TP53CHRM3KMT2A | |
| SCHEMBL25913609 | 0.71 | SCN1A (0.48) | MEN1HPGDKMT2A | |
| SCHEMBL9872973 | 0.70 | HTR3A (0.66) | HTR1ACYP3A4ADRA2BADRA2CCHRM3 | |
| SCHEMBL24848168 | 0.70 | MEN1 (0.46) | MEN1TP53KMT2A | |
| SCHEMBL5010378 | 0.70 | PARP10 (0.44) | MEN1KMT2APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451185-A1 | INDOLE-2-CARBOXAMIDES AS FACTOR XA INHIBITORS | Aventis Pharma Deutschland GmbH (DE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003044014-A1 | INDOLE-2-CARBOXAMIDES AS FACTOR XA INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-05-30 | — | — | WO | disclosed |