Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | PRKCZ | Q05513 | 8/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | PRKCI | P41743 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MPI | P34949 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749686 | 0.93 | ALDH1A1 (0.61) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL689612 | 0.89 | HSD17B10 (0.77) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL8288638 | 0.89 | PRKCZ (0.72) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL8288636 | 0.88 | ALDH1A1 (0.70) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL689202 | 0.86 | PRKCZ (0.73) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL8289775 | 0.86 | ALDH1A1 (0.69) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL689025 | 0.86 | PRKCZ (0.73) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL3974980 | 0.86 | ALDH1A1 (0.65) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL1190649 | 0.85 | PRKCZ (0.80) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 | |
| SCHEMBL689790 | 0.85 | ALDH1A1 (0.78) | ALDH1A1MAPTMAPK1PRKCZHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |
| US-20090137603-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1953148-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137603-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | MMP2, MMP9, MMP1 | ALDH1A1 423/4885MAPT 4287/4885MAPK1 1734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.