Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | PRKCZ | Q05513 | 9/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | PRKCI | P41743 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.62 |
| ▸ | MPI | P34949 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288638 | 0.90 | PRKCZ (0.72) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL8288636 | 0.89 | ALDH1A1 (0.70) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL689305 | 0.89 | ALDH1A1 (0.70) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL8289775 | 0.88 | ALDH1A1 (0.69) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL689025 | 0.88 | PRKCZ (0.73) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL689202 | 0.88 | PRKCZ (0.73) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL1190649 | 0.87 | PRKCZ (0.80) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL5919161 | 0.87 | PRKCZ (0.75) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL689790 | 0.86 | ALDH1A1 (0.78) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ | |
| SCHEMBL8289405 | 0.85 | PRKCZ (0.74) | HSD17B10ALDH1A1MAPTMAPK1PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029545-B2 | Thienopyridine NOX2 inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2015-05-12 | — | — | US | disclosed |
| US-20120252805-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| EP-1383463-B1 | FUSED THIOPHENE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF CHRONIC PAIN | KING PHARMACEUTICALS INC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |
| US-20090137603-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1383463-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-7449490-B2 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| EP-1953148-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-08-06 | — | — | EP | disclosed |
| US-7101905-B2 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-20060183921-A1 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2006-08-17 | — | — | US | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
| EP-1383463-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | King Pharmaceuticals, Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20030073733-A1 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2003-04-17 | — | — | US | disclosed |
| WO-2002083083-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| EP-1095044-A1 | PIPERAZYNIL PYRIMIDINE DIONE COMPOUNDS SELECTIVE FOR ADRENOCEPTORS | ABBOTT LABORATORIES (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6166019-A | Piperazinyl pyrimidine dione compounds selective for adrenoceptors | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |
| US-6153614-A | Piperazinyl pyrimidine dione compounds selective for adrenoceptors | ABBOTT LABORATORIES (US) | 2000-11-28 | — | — | US | disclosed |
| WO-2000004027-A1 | PIPERAZYNIL PYRIMIDINE DIONE COMPOUNDS SELECTIVE FOR ADRENOCEPTORS | ABBOTT LABORATORIES (US) | 2000-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252805-A1 | NOVEL COMPOUNDS | CYBB, NOX1, NOX4 | HSD17B10 362/4885ALDH1A1 734/4885MAPT 1781/4885 |
| US-20060183921-A1 | Pharmaceutically active compounds and methods of use | TRPV1, TPMT, ACHE | HSD17B10 2648/4885ALDH1A1 1591/4885MAPT 1176/4885 |
| US-20030073733-A1 | Pharmaceutically active compounds and methods of use | TRPV1, TPMT, ACHE | HSD17B10 2648/4885ALDH1A1 1591/4885MAPT 1176/4885 |
| US-20090137603-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | MMP2, MMP9, MMP1 | HSD17B10 832/4885ALDH1A1 423/4885MAPT 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.