Alethine

Alethine

SCHEMBL689905

NCCC(=O)NCCSSCCNC(=O)CCN

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
LMNA P02545 2/20 0.40
CA1 P00915 2/20 0.39
CA2 P00918 2/20 0.39
CA9 Q16790 1/20 0.39
MEN1 O00255 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39
MMP2 P08253 1/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 2/20 0.36
SLC6A5 Q9Y345 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
CASP2 P42575 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508397 0.87 CASP2 (0.39) TSHRCYP3A4CYP2D6CYP2C19LMNA
SCHEMBL9505929 0.87 CA1 (0.43) TSHRLMNACA1CA2CA9
SCHEMBL21326872 0.84 CYP2C19 (0.33) TSHRCYP3A4CYP2D6CYP2C19LMNA
SCHEMBL9506141 0.84 CASP2 (0.46) TSHRCYP3A4CYP2D6CYP2C19LMNA
SCHEMBL9506124 0.84 SLC6A5 (0.51) CYP3A4CYP2D6LMNAMEN1KMT2A
SCHEMBL3548845 0.83 ALDH1A1 (0.54) TSHRCYP3A4CYP2D6CYP2C19LMNA
SCHEMBL16227684 0.82 TSHR (0.43) TSHRCYP2D6LMNACA1CA2
SCHEMBL14547392 0.82 CASP2 (0.48) TSHRLMNAALDH1A1HPGDSLC6A5
SCHEMBL15684647 0.82 TDP1 (0.44) CYP3A4CA1CA2CA9MEN1
SCHEMBL6319788 0.81 CA2 (0.38) TSHRLMNACA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1056 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-20210060040-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2021-03-04 US claimed
EP-3534933-A1 BETA-ALETHINE, IMMUNE MODULATORS, AND USES THEREOF Aximmune, Inc. (US) 2019-09-11 EP claimed
CN-109069470-A Use of specific benzodihydrofuran lignans for inhibiting breast cancer cell metastasis 杨宁荪 2018-12-21 CN claimed
US-20170304327-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2017-10-26 US claimed
EP-3187184-A1 COMBINATION THERAPIES FOR HEMATOLOGIC MALIGNANCIES Gilead Calistoga LLC (US) 2017-07-05 EP claimed
US-20170119771-A1 COMBINATION THERAPIES FOR HEMATOLOGIC MALIGNANCIES GILEAD SCIENCES, INC. 2017-05-04 US claimed
CN-106163524-A 7-benzyl-4- (2-methylbenzyl) -2,4,6,7,8, 9-hexahydroimidazo [1,2-a ] pyrido [3,4-e ] pyrimidin-5 (1H) -one, salts thereof, and methods of use 昂克希尔迪克斯有限公司 2016-11-23 CN claimed
EP-2683377-A1 COMBINATION THERAPIES FOR HEMATOLOGIC MALIGNANCIES Gilead Calistoga LLC (US) 2014-01-15 EP claimed
US-8540967-B2 Porphyrazine optical and dual optical/MR contrast and therapeutic agents HOFFMAN/BARRETT, L.L.C. (US) 2013-09-24 US claimed
JP-3319597-B2 2002-09-03 JP claimed
EP-0636022-A1 CHEMICAL PREVENTION OR REVERSAL OF CATARACT BY PHASE SEPARATION INHIBITORS OCULON CORPORATION (US) 1995-02-01 EP claimed
WO-1994026259-A1 CHEMICAL PREVENTION OR REVERSAL OF CATARACT BY PHASE SEPARATION INHIBITORS OCULON CORPORATION (US) 1994-11-24 WO claimed
EP-0539525-A4 1994-01-12 EP claimed
WO-1993020805-A1 CHEMICAL PREVENTION OR REVERSAL OF CATARACT BY PHASE SEPARATION INHIBITORS OCULON CORPORATION (US) 1993-10-28 WO claimed
EP-0432000-B1 REDUCING COMPOSITION FOR PERMANENT HAIRWAVING, COMPRISING AS REDUCING AGENT AN AMINO-MERCAPTOALKYLAMIDE OR ONE OF ITS SALTS, AND ITS USE IN A PROCESS FOR PERMANENT HAIRWAVING L'OREAL (FR) 1993-08-11 EP claimed
EP-0538330-A4 BETA-ALETHINE USE IN CELL CULTURE AND THERAPY 1993-07-07 EP claimed
EP-0539525-A1 VITALETHEINE AND USE IN CELL CULTURE AND THERAPY UNIVERSITY OF NEW MEXICO (US) 1993-05-05 EP claimed
EP-0538330-A1 BETA-ALETHINE USE IN CELL CULTURE AND THERAPY. UNIV NEW MEXICO (US) 1993-04-28 EP claimed
WO-1992000960-A1 BETA-ALETHINE USE IN CELL CULTURE AND THERAPY UNIVERSITY OF NEW MEXICO (US) 1992-01-23 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170119771-A1 COMBINATION THERAPIES FOR HEMATOLOGIC MALIGNANCIES BCL6, HCLS1, MCL1 TSHR 3369/4885CYP3A4 4397/4885CYP2D6 3768/4885
US-20210060040-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, GPR18 TSHR 784/4885CYP3A4 1213/4885CYP2D6 800/4885
US-20170304327-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, GPR18 TSHR 784/4885CYP3A4 1213/4885CYP2D6 800/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.