Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11087067 | 0.98 | KMT2A (0.50) | ALDH1A1KMT2APOLBGAAMAPT | |
| SCHEMBL16236818 | 0.87 | POLB (0.42) | ALDH1A1KMT2APOLBGAAMAPT | |
| SCHEMBL12178218 | 0.82 | KMT2A (0.48) | ALDH1A1KMT2APOLBGAAMAPT | |
| SCHEMBL8168077 | 0.81 | DHFR (0.46) | KMT2APOLBGAAMAPTL3MBTL1 | |
| SCHEMBL10010025 | 0.79 | POLB (0.46) | ALDH1A1KMT2APOLBGAAMAPT | |
| SCHEMBL42399 | 0.79 | MTNR1B (0.57) | ALDH1A1KMT2APOLBMAPTNPC1 | |
| SCHEMBL38660132 | 0.79 | MTNR1B (0.57) | ALDH1A1KMT2APOLBMAPTNPC1 | |
| SCHEMBL22421831 | 0.77 | DYRK1A (0.42) | ALDH1A1KMT2APOLBCYP1A1CYP1B1 | |
| SCHEMBL28471149 | 0.77 | MTNR1B (0.55) | ALDH1A1KMT2APOLBMAPTNPC1 | |
| 1,3,5-Trimethoxybenzene SCHEMBL27413401 | 0.76 | ALDH1A1 (0.69) | ALDH1A1KMT2APOLBCYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104130257-A | One-dimensional organic semiconductor spiral nano-wires with fluorescence response upon organic amine gases, and preparation method and application thereof | CHINESE ACAD INST CHEMISTRY | 2014-11-05 | — | — | CN | claimed |
| JP-11005770-A | — | — | None | — | — | JP | disclosed |
| US-20220332687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | SANOFI (FR) | 2022-10-20 | — | — | US | disclosed |
| US-11229649-B2 | Methods for treating cryptosporidiosis using triazolopyridazines | UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 2022-01-25 | — | — | US | disclosed |
| US-11014923-B2 | Bicyclic heterocycles as FGFR4 inhibitors | INCYTE CORPORATION (US) | 2021-05-25 | — | — | US | disclosed |
| US-11008290-B2 | Halogenated quinoline derivatives as antimicrobial agents | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2021-05-18 | — | — | US | disclosed |
| US-20200399267-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | INCYTE CORPORATION | 2020-12-24 | — | — | US | disclosed |
| EP-2740729-B1 | QUINAZOLINE DERIVATIVE, COMPOSITION HAVING THE DERIVATIVE, AND USE OF THE DERIVATIVE IN PREPARING MEDICAMENT | HANGZHOU MINSHENG INSTITUTES FOR PHARMA RES (CN) | 2020-11-25 | — | — | EP | disclosed |
| CN-107088414-B | A kind of N- ethylization catalyst and its preparing the application in N-ethylaniline derivative | 湖北新德晟材料科技有限公司 | 2019-09-10 | — | — | CN | disclosed |
| EP-3057943-B1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2018-04-25 | — | — | EP | disclosed |
| US-6703392-B2 | OREXIN RECEPTOR ANTAGONISTS FOR OBESITY OR SLEEPING DISORDER TREATMENT | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-03-09 | — | — | US | disclosed |
| US-20030176415-A1 | 1,2,3,4-tetrahydroisoquinoline derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2003-09-18 | — | — | US | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |
| JP-H115770-A | PRODUCTION OF N-ETHYL-3,5-DIMETHOXY-4-FLUOROANILINE | WAKO PURE CHEM IND LTD | 1999-01-12 | — | — | JP | disclosed |
| WO-1995011880-A1 | SUBSTITUTED AMIDES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-05-04 | — | — | WO | disclosed |
| US-4442291-A | INTERMEDIATE FOR ANTIPSYCHOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4388467-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1983-06-14 | — | — | US | disclosed |
| US-4349678-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4334070-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4260762-A | NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1981-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11229649-B2 | Methods for treating cryptosporidiosis using triazolopyridazines | CLPP, SI, SAMHD1 | ALDH1A1 1257/4885KMT2A 3111/4885POLB 2020/4885 |
| US-11014923-B2 | Bicyclic heterocycles as FGFR4 inhibitors | FGFR4, FGFR1, FGFR3 | ALDH1A1 901/4885KMT2A 1045/4885POLB 2931/4885 |
| US-20220332687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | ALDH1A1 684/4885KMT2A 3318/4885POLB 3726/4885 |
| US-20200399267-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | FGFR4, FGFR1, FGFR3 | ALDH1A1 901/4885KMT2A 1045/4885POLB 2931/4885 |
| US-20030176415-A1 | 1,2,3,4-tetrahydroisoquinoline derivatives | HCRTR2, HCRTR1, NPY2R | ALDH1A1 1115/4885KMT2A 1396/4885POLB 4785/4885 |
| US-11008290-B2 | Halogenated quinoline derivatives as antimicrobial agents | NDUFS5, NDUFS7, NDUFS3 | ALDH1A1 553/4885KMT2A 1438/4885POLB 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.