Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.53 |
| ▸ | DPP4 | P27487 | 7/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | TGM1 | P22735 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901844 | 0.86 | CTSL (0.53) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL6902881 | 0.84 | TGM2 (0.69) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL31065853 | 0.81 | SIGMAR1 (0.70) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL6901323 | 0.80 | MEN1 (0.54) | ALDH1A1GAAMEN1KMT2ADPP4 | |
| SCHEMBL24677036 | 0.79 | ALDH1A1 (0.58) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL1870659 | 0.79 | TGM2 (0.72) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL3948456 | 0.78 | ALDH1A1 (0.85) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL381922 | 0.78 | ALDH1A1 (0.85) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL3948461 | 0.78 | ALDH1A1 (0.85) | CTSLCTSBCTSKTSHRALDH1A1 | |
| SCHEMBL1870932 | 0.78 | ALDH1A1 (0.67) | CTSLCTSBCTSKTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |