Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972546 | 0.89 | SIGMAR1 (0.47) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL6902704 | 0.84 | CYP3A4 (0.55) | ALDH1A1CYP3A4KDM4ELMNAPOLB | |
| SCHEMBL6903539 | 0.83 | ALDH1A1 (0.48) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL4113945 | 0.79 | SIGMAR1 (0.45) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL6905792 | 0.79 | NCF1 (0.44) | ALDH1A1HPGDCYP3A4NPC1RAB9A | |
| SCHEMBL6314684 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL17577878 | 0.74 | SIGMAR1 (0.44) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL9715426 | 0.74 | CYP3A4 (0.35) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL15453222 | 0.74 | SIGMAR1 (0.47) | ALDH1A1HPGDCYP3A4TSHRHSD17B10 | |
| SCHEMBL1486298 | 0.71 | SIGMAR1 (0.53) | ALDH1A1TSHRHSD17B10TDP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379517-A2 | ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2004-01-14 | — | — | EP | claimed |
| US-6548548-B2 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2003-04-15 | — | — | US | claimed |
| US-20020111364-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2002-08-15 | — | — | US | claimed |
| WO-2002046181-A2 | ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2002-06-13 | — | — | WO | claimed |
| EP-1379517-A2 | ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2004-01-14 | — | — | EP | disclosed |
| US-6548548-B2 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2003-04-15 | — | — | US | disclosed |
| US-20020111364-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2002-08-15 | — | — | US | disclosed |
| WO-2002046181-A2 | ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111364-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | ALDH1A1 399/4885HPGD 1166/4885CYP3A4 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.