Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6903434 | 0.83 | ALDH1A1 (0.48) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL6314684 | 0.76 | ALDH1A1 (0.58) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL6899849 | 0.74 | EGFR (0.37) | ALDH1A1CYP3A4HSD17B10KMT2ANPC1 | |
| SCHEMBL15561429 | 0.70 | ALDH1A1 (0.50) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL7220660 | 0.70 | BCL2L1 (0.38) | ALDH1A1CYP3A4HPGDTSHRSIGMAR1 | |
| SCHEMBL972546 | 0.70 | SIGMAR1 (0.47) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL4941999 | 0.68 | ALDH1A1 (1.00) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL29413841 | 0.68 | ALDH1A1 (1.00) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL9029 | 0.68 | ALDH1A1 (1.00) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 | |
| SCHEMBL6509235 | 0.66 | SIGMAR1 (0.52) | ALDH1A1CYP3A4HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1478085-A | ABCA-1 elevating compounds against coronary artery disease or atherosclerosis | CV���ƹ�˾ | 2004-02-25 | — | — | CN | disclosed |
| EP-1379517-A2 | ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2004-01-14 | — | — | EP | disclosed |
| US-6548548-B2 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2003-04-15 | — | — | US | disclosed |
| US-20020111364-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2002-08-15 | — | — | US | disclosed |
| WO-2002046181-A2 | ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS | CV THERAPEUTICS, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111364-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | ALDH1A1 399/4885CYP3A4 1597/4885HPGD 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.