Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6911528 | 0.82 | ALDH1A1 (0.35) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| SCHEMBL28054199 | 0.67 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| SCHEMBL28054227 | 0.62 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| SCHEMBL29763176 | 0.57 | TRPA1 (0.70) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| SCHEMBL8047684 | 0.57 | TRPA1 (0.70) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| SCHEMBL17876987 | 0.56 | SMN1; SMN2 (0.46) | ALDH1A1TRPA1NPC1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL6911523 | 0.56 | MAOA (0.32) | — | |
| Chamazulene SCHEMBL29562128 | 0.56 | LMNA (0.50) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| Chamazulene SCHEMBL180449 | 0.56 | LMNA (0.50) | ALDH1A1KDM4EGAAHPGDTRPA1 | |
| Hydrochloric Acid SCHEMBL3683321 | 0.56 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAAHPGDTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790917-B2 | POLYMERIZING A VINYL COMPOUND IN PRESENCE OF A CATALYST OBTAINED BY COMBINING ORGANOTRANSITION METAL COMPOUND, AN ALUMINUM COMPUND OR ALUMOXANE AND A BORON COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-09-14 | — | — | US | disclosed |
| US-20020198340-A1 | Process for producing vinyl compound polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-12-26 | — | — | US | disclosed |