Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CLPP | Q16740 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 2/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302876 | 0.87 | CLPP (0.41) | GABRA1GABRA2GABRA3GABRA5ACHE | |
| SCHEMBL2306533 | 0.85 | PRMT5 (0.41) | GABRA1GABRA2GABRA3GABRA5CLPP | |
| SCHEMBL2340797 | 0.82 | GABRA1 (0.54) | GABRA1GABRA2GABRA3GABRA5KDM4E | |
| SCHEMBL6908503 | 0.79 | ACHE (0.48) | GABRA1GABRA2ACHEKDM4EALDH1A1 | |
| SCHEMBL2357883 | 0.77 | PRMT5 (0.41) | GABRA1GABRA2GABRA3GABRA5CLPP | |
| SCHEMBL6909368 | 0.76 | DRD2 (0.45) | GABRA1GABRA2GABRA3ACHEKDM4E | |
| SCHEMBL2303580 | 0.76 | ACHE (0.53) | GABRA1GABRA2GABRA3GABRA5ACHE | |
| SCHEMBL2302421 | 0.76 | MEN1 (0.56) | GABRA1GABRA2ACHECLPPSLC6A5 | |
| SCHEMBL6909775 | 0.76 | CLPP (0.43) | KDM4EALDH1A1CLPPTP53 | |
| SCHEMBL6909376 | 0.76 | KMT2A (0.51) | GABRA1GABRA2ACHEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101804-A1 | PYRAZOLO PIPERIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-08-25 | — | — | WO | disclosed |