SCHEMBL69259

SCHEMBL69259

Oc1cc(O)c(Cl)cc1Cl

nearest known ligand 0.80

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 10/20 0.80
TSHR P16473 8/20 0.80
HPGD P15428 6/20 0.80
CYP3A4 P08684 5/20 0.50
ALDH1A1 P00352 4/20 0.50
TDP1 Q9NUW8 1/20 0.50
CASP1 P29466 1/20 0.50
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
HSP90AA1 P07900 3/20 0.45
MAPK1 P28482 2/20 0.45
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42
TTR P02766 1/20 0.42
RECQL P46063 1/20 0.42
ADRA1A P35348 1/20 0.42
ESR2 Q92731 1/20 0.40
AHR P35869 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL592892 0.89 HSD17B10 (0.75) HSD17B10TSHRHPGDCYP3A4ALDH1A1
Triclofenol SCHEMBL1338 0.89 HSD17B10 (1.00) HSD17B10TSHRHPGDCYP3A4ALDH1A1
Triclofenol SCHEMBL29387498 0.89 HSD17B10 (1.00) HSD17B10TSHRHPGDCYP3A4ALDH1A1
SCHEMBL48305 0.88 HSD17B10 (0.86) HSD17B10TSHRHPGDCYP3A4ALDH1A1
Triclofenol SCHEMBL2813598 0.86 HSD17B10 (0.93) HSD17B10TSHRHPGDCYP3A4ALDH1A1
SCHEMBL8640677 0.78 TSHR (0.52) HSD17B10TSHRHPGDCYP3A4ALDH1A1
SCHEMBL13623675 0.78 HSD17B10 (0.60) HSD17B10TSHRHPGDCYP3A4ALDH1A1
SCHEMBL11714444 0.78 HSD17B10 (0.60) HSD17B10TSHRHPGDCYP3A4ALDH1A1
SCHEMBL4853924 0.78 HSD17B10 (0.60) HSD17B10TSHRHPGDCYP3A4ALDH1A1
SCHEMBL13855825 0.78 HSD17B10 (0.52) HSD17B10TSHRHPGDCYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1931 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025242864-A1 DISCOLORING COMPOSITION FOR KERATIN FIBERS DYED WITH BLEACH-STABLE DIRECT DYES KAO CORPORATION (JP) 2025-11-27 WO claimed
EP-4408377-B1 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES KAO CORP (JP) 2025-10-08 EP claimed
US-12383482-B2 Hair coloring compositions WELLA GERMANY GMBH (DE) 2025-08-12 US claimed
US-20240390243-A1 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES KAO CORPORATION (JP) 2024-11-28 US claimed
US-20240390244-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE SALT KAO CORPORATION (JP) 2024-11-28 US claimed
US-20240382394-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE AND AMINE SALT KAO CORPORATION (JP) 2024-11-21 US claimed
EP-4251285-B1 HAIR COLORING COMPOSITIONS WELLA INT OPERATIONS SWITZERLAND SARL (CH) 2024-09-04 EP claimed
EP-4408377-A2 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES Kao Corporation (JP) 2024-08-07 EP claimed
EP-4408378-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE SALT Kao Corporation (JP) 2024-08-07 EP claimed
US-20240024218-A1 HAIR COLORING COMPOSITIONS WELLA GERMANY GMBH (DE) 2024-01-25 US claimed
US-4745652-A DEVELOPERS FOR DYES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1988-05-24 US claimed
US-4725282-A LOW VISCOSITY; STORAGE STABILITY WELLA AKTIENGESELLSCHAFT (DE) 1988-02-16 US claimed
US-4713080-A OXIDATIVE COLORING WELLA AKTIENGESELLSCHAFT (DE) 1987-12-15 US claimed
EP-0166155-B1 2-ALKYLSULPHONYL-1,4-DIAMINOBENZENES, PROCESS FOR THEIR PREPARATION AND OXIDATIVE HAIR-DYEING COMPOSITIONS CONTAINING THESE COMPOUNDS Wella Aktiengesellschaft (DE) 1987-09-23 EP claimed
US-4661114-A COUPLERS WELLA AKTIENGESELLSCHAFT (DE) 1987-04-28 US claimed
US-4588410-A DEVELOPERS, COUPLERS WELLA AKTIENGESELLSCHAFT (DE) 1986-05-13 US claimed
US-4543425-A 1,3-Diamino-4-(2',2',2',-trifluoroethoxy)-benzene, method of producing the same, and hair coloring composition containing the same WELLA AG (DE) 1985-09-24 US claimed
US-4487975-A Etherification of phenols RHONE-POULENC INDUSTRIES (FR) 1984-12-11 US claimed
EP-0122523-A2 Diazotype compositions and materials Andrews Paper and Chemical Co., Inc. (US) 1984-10-24 EP claimed
US-3965033-A Process for the production of oil-containing microcapsules FUJI PHOTO FILM CO., LTD. (JA) 1976-06-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240390243-A1 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES KRT18, CYBA, CYBB HSD17B10 267/4885TSHR 3954/4885HPGD 207/4885
US-20240390244-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE SALT CS, SDHA, MDH2 HSD17B10 444/4885TSHR 4446/4885HPGD 182/4885
US-20240382394-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE AND AMINE SALT KRT18, AOC1, MUC1 HSD17B10 1184/4885TSHR 4629/4885HPGD 460/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.