SCHEMBL6929031

SCHEMBL6929031

Clc1ccc2nc(Cl)c3ncn(CCC4CCNCC4)c3c2c1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 1/20 0.40
NPY1R P25929 4/20 0.40
PIM1 P11309 2/20 0.39
NR3C1 P04150 1/20 0.39
PRPS1 P60891 2/20 0.36
IRAK4 Q9NWZ3 1/20 0.36
ACP1 P24666 3/20 0.35
LMNA P02545 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
KDM4E B2RXH2 1/20 0.34
S1PR2 O95136 1/20 0.34
KMT2A Q03164 1/20 0.34
HIF1A Q16665 1/20 0.34
TGFBR1 P36897 2/20 0.34
MAOB P27338 1/20 0.34
HTR6 P50406 1/20 0.34
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6926216 0.90 NR3C1 (0.38) NPY1RNR3C1IRAK4LMNANPSR1
SCHEMBL6929405 0.87 KDM4E (0.42) NPY1RNR3C1IRAK4ACP1KDM4E
SCHEMBL6925999 0.87 ACHE (0.43) SLC6A4NPY1RPIM1NR3C1ACP1
Trifluoroacetic Acid SCHEMBL6928326 0.82 NR3C1 (0.45) NPY1RPIM1NR3C1PRPS1ACP1
SCHEMBL6922241 0.81 NPY1R (0.40) SLC6A4NPY1RPIM1ACP1TGFBR1
SCHEMBL6930321 0.78 NPY1R (0.43) SLC6A4NPY1RPIM1ACP1LMNA
SCHEMBL6096772 0.74 TLR7 (0.56) SLC6A4NPY1RLMNANPSR1TSHR
Hydrochloric Acid SCHEMBL6929408 0.73 TLR7 (0.55) SLC6A4NPY1RLMNANPSR1TSHR
SCHEMBL6838687 0.72 HTR4 (0.41) SLC6A4NPY1RNR3C1PRPS1ACP1
SCHEMBL405370 0.71 IKBKB (0.44) NPSR1KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6518265-B1 1H-imidazopyridine derivatives HOKURIKU SEIYAKU CO., LTD. (JP) 2003-02-11 US disclosed
EP-1104764-A1 1H-IMIDAZOPYRIDINE DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2001-06-06 EP disclosed