Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | ARRB1 | P49407 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939845 | 0.90 | TRPA1 (0.38) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| SCHEMBL6940278 | 0.90 | SIGMAR1 (0.36) | P2RX7KMT2AOPRM1TRPA1SLC6A2 | |
| SCHEMBL5846181 | 0.88 | ALDH1A1 (0.38) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| SCHEMBL6937466 | 0.88 | DPP4 (0.35) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5846854 | 0.87 | ALDH1A1 (0.38) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| SCHEMBL6937424 | 0.84 | TRPA1 (0.44) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| SCHEMBL6937028 | 0.84 | TRPA1 (0.38) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| SCHEMBL6937427 | 0.83 | TRPA1 (0.38) | KMT2AOPRM1TRPA1SLC6A2SLC6A4 | |
| SCHEMBL6941995 | 0.82 | ESR1 (0.37) | P2RX7L3MBTL1SMN1; SMN2KMT2AOPRM1 | |
| SCHEMBL6939503 | 0.81 | TRPA1 (0.36) | P2RX7KMT2AOPRM1TRPA1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |