SCHEMBL694541

SCHEMBL694541

COc1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)O)n2)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.43
HSD17B10 Q99714 1/20 0.43
KMO O15229 2/20 0.41
ALPL P05186 1/20 0.36
HSP90AA1 P07900 2/20 0.36
HSP90AB1 P08238 2/20 0.36
PRKAB2 O43741 1/20 0.36
PRKAG1 P54619 1/20 0.36
PRKAA2 P54646 1/20 0.36
PRKAA1 Q13131 1/20 0.36
PRKAG3 Q9UGI9 1/20 0.36
PRKAG2 Q9UGJ0 1/20 0.36
PRKAB1 Q9Y478 1/20 0.36
CYP3A4 P08684 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
TPMT P51580 1/20 0.35
TSHR P16473 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.34
EIF4E P06730 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29349463 0.91 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMOHSP90AA1
SCHEMBL29405327 0.91 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMOHSP90AA1
SCHEMBL115379 0.91 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMOHSP90AA1
SCHEMBL3841986 0.90 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMOALPL
Potassium SCHEMBL679681 0.90 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMOHSP90AA1
SCHEMBL679679 0.90 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMOHSP90AA1
SCHEMBL3326424 0.89 ALPL (0.43) ALDH1A1KDM4EHSD17B10ALPLHSP90AA1
SCHEMBL30481033 0.89 ALPL (0.43) ALDH1A1KDM4EHSD17B10ALPLHSP90AA1
SCHEMBL16047307 0.88 KMO (0.40) ALDH1A1KDM4EHSD17B10KMOHSP90AA1
SCHEMBL2462589 0.88 HSD17B10 (0.37) ALDH1A1KDM4EHSD17B10KMOHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
US-9040458-B2 Safening composition of 6-(trisubstituded phenyl)-4-amino-2-pyridinecarboxylate herbicides and cloquintocet-mexyl for cereal crops DOW AGROSCIENCES LLC (US) 2015-05-26 US claimed
US-8921267-B2 Safening 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide injury on cereal crops DOW AGROSCIENCES, LLC. (US) 2014-12-30 US claimed
US-8916498-B2 Safening 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide injury on direct seeded and transplanted paddy rice DOW AGROSCIENCES, LLC. (US) 2014-12-23 US claimed
US-20140100109-A1 SAFENING COMPOSITION OF 6-(TRISUBSTITUDED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS CORTEVA AGRISCIENCE LLC 2014-04-10 US claimed
US-8609586-B2 Safening composition of 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicides and cloquintocet-mexyl for cereal crops DOW AGROSCIENCES, LLC. (US) 2013-12-17 US claimed
US-20130281293-A1 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS CORTEVA AGRISCIENCE LLC 2013-10-24 US claimed
EP-2361013-B1 SAFENING COMPOSITION OF 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS DOW AGROSCIENCES LLC (US) 2013-10-02 EP claimed
US-8530383-B2 Safening 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide injury on cereal crops DOW AGROSCIENCES LLC (US) 2013-09-10 US claimed
EP-2361013-A2 SAFENING COMPOSITION OF 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS Dow AgroSciences LLC (US) 2011-08-31 EP claimed
EP-2361014-A2 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS Dow AgroSciences LLC (US) 2011-08-31 EP claimed
EP-2352371-A2 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON DIRECT SEEDED AND TRANSPLANTED PADDY RICE Dow AgroSciences LLC (US) 2011-08-10 EP claimed
US-20100130362-A1 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS DOW AGROSCIENCES LLC (US) 2010-05-27 US claimed
WO-2010059680-A2 SAFENING COMPOSITION OF 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS DOW AGROSCIENCES LLC (US) 2010-05-27 WO claimed
WO-2010059671-A2 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON DIRECT SEEDED AND TRANSPLANTED PADDY RICE DOW AGROSCIENCES LLC (US) 2010-05-27 WO claimed
US-20100130363-A1 SAFENING COMPOSITION OF 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS DOW AGROSCIENCES LLC (US) 2010-05-27 US claimed
US-20100130361-A1 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON DIRECT SEEDED AND TRANSPLANTED PADDY RICE DOW AGROSCIENCES LLC (US) 2010-05-27 US claimed
WO-2010059676-A2 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS DOW AGROSCIENCES LLC (US) 2010-05-27 WO claimed
US-10556865-B2 Synergistic herbicidal composition containing certain pyridine or pyrimidine carboxylic acids and certain cereal and rice herbicides DOW AGROSCIENCES LLC (US) 2020-02-11 US disclosed
WO-2007082098-A2 6-(POLY-SUBSTITUTED ARYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-07-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140100109-A1 SAFENING COMPOSITION OF 6-(TRISUBSTITUDED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS PLPBP, MTX2, ABAT ALDH1A1 3739/4885KDM4E 1061/4885HSD17B10 2838/4885
US-20130281293-A1 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS DDT, DBF4, DHFR ALDH1A1 2318/4885KDM4E 2776/4885HSD17B10 2264/4885
US-10556865-B2 Synergistic herbicidal composition containing certain pyridine or pyrimidine carboxylic acids and certain cereal and rice herbicides DHFR, DPYD, DDT ALDH1A1 384/4885KDM4E 1949/4885HSD17B10 949/4885
US-20100130361-A1 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON DIRECT SEEDED AND TRANSPLANTED PADDY RICE DDT, CYP4F3, CYP3A43 ALDH1A1 509/4885KDM4E 2509/4885HSD17B10 1319/4885
US-20100130362-A1 SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS DDT, DBF4, DHFR ALDH1A1 2318/4885KDM4E 2776/4885HSD17B10 2264/4885
US-20100130363-A1 SAFENING COMPOSITION OF 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS PLPBP, MTX2, CIP2A ALDH1A1 3499/4885KDM4E 1424/4885HSD17B10 2778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.