Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumagillin SCHEMBL13819097 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL8130 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL18517986 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL17959149 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL12526078 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL18517793 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL15263951 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL13304359 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL15745869 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL18517985 | 1.00 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230190938-A1 | NOVEL CARGO DELIVERY SYSTEM AND COMPOSITION COMPRISING THE SAME | SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) | 2023-06-22 | — | — | US | disclosed |
| US-20230190938-A1 | NOVEL CARGO DELIVERY SYSTEM AND COMPOSITION COMPRISING THE SAME | SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) | 2023-06-22 | — | — | US | disclosed |
| US-20210299253-A1 | NOVEL AUTOTAC CHIMERIC COMPOUND, AND COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING DISEASES THROUGH TARGETED PROTEIN DEGRADATION COMPRISING THE SAME | PROTECH CO., LTD. (KR) | 2021-09-30 | — | — | US | disclosed |
| US-10406134-B2 | Methods of treating an overweight subject | ZAFGEN, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190224156-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN INC (US) | 2019-07-25 | — | — | US | disclosed |
| US-20190022051-A1 | METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | ZAFGEN INC (US) | 2019-01-24 | — | — | US | disclosed |
| US-9925166-B2 | Methods of treating an overweight or obese subject | ZAFGEN, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-9925166-B2 | Methods of treating an overweight or obese subject | ZAFGEN, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-20180064677-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN INC (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180055811-A1 | METHODS OF TREATING AN OVERWEIGHT SUBJECT | VANDERBILT UNIVERSITY (US) | 2018-03-01 | — | — | US | disclosed |
| US-20100184853-A1 | TERPENES WITH ANTIFUNGAL ACTIVITY AGAINST MALASSEZIA YEASTS | INSTITUTO BIOMAR, S.A. (ES) | 2010-07-22 | — | — | US | disclosed |
| WO-2010065883-A2 | METHOD OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | ZAFGEN CORPORATION (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010009374-A1 | METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | ZAFGEN, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| US-20100016425-A1 | METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | ZAFGEN, INC. (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016425-A1 | METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | ZAFGEN, INC. (US) | 2010-01-21 | — | — | US | disclosed |
| WO-2008152127-A1 | TERPENES WITH ANTIFUNGAL ACTIVITY AGAINST MALASSEZIA YEASTS | INSTITUTO BIOMAR, S.A. (ES) | 2008-12-18 | — | — | WO | disclosed |
| US-20080200402-A1 | Use Of Fumagillin And The Derivatives Thereof To Increase The Bioavilability Of The Macrocyclic Lactones | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR) | 2008-08-21 | — | — | US | disclosed |
| US-20080200402-A1 | Use Of Fumagillin And The Derivatives Thereof To Increase The Bioavilability Of The Macrocyclic Lactones | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR) | 2008-08-21 | — | — | US | disclosed |
| WO-2006131649-A2 | USE OF FUMAGILLIN AND THE DERIVATIVES THEREOF TO INCREASE THE BIOAVAILABILITY OF THE MACROCYCLIC LACTONES | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR) | 2006-12-14 | — | — | WO | disclosed |
| US-6528539-B1 | And propylene glycol dicaprate/dicaprylate hydrophobic agent | SANOFI-SYNTHELABO (FR) | 2003-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200402-A1 | Use Of Fumagillin And The Derivatives Thereof To Increase The Bioavilability Of The Macrocyclic Lactones | ABCB1, SLC47A1, ABCC1 | METAP2 3141/4885ABCB11 4/4885LMNA 1924/4885 |
| US-20180055811-A1 | METHODS OF TREATING AN OVERWEIGHT SUBJECT | METAP2, CPT1B, SLC5A2 | METAP2 1/4885ABCB11 1980/4885LMNA 3061/4885 |
| US-10406134-B2 | Methods of treating an overweight subject | METAP2, CPT1B, SLC5A2 | METAP2 1/4885ABCB11 1980/4885LMNA 3061/4885 |
| US-20100016425-A1 | METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | LIPC, FABP4, LPL | METAP2 777/4885ABCB11 118/4885LMNA 1627/4885 |
| US-20230190938-A1 | NOVEL CARGO DELIVERY SYSTEM AND COMPOSITION COMPRISING THE SAME | ATG7, SQSTM1, BECN1 | METAP2 3678/4885ABCB11 419/4885LMNA 1560/4885 |
| US-20180064677-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, ADIPOR2, FABP4 | METAP2 1/4885ABCB11 4284/4885LMNA 4501/4885 |
| US-20100184853-A1 | TERPENES WITH ANTIFUNGAL ACTIVITY AGAINST MALASSEZIA YEASTS | CYP51A1, ERG28, DPM1 | METAP2 2908/4885ABCB11 411/4885LMNA 3866/4885 |
| US-20190022051-A1 | METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT | LIPC, FABP4, LPL | METAP2 777/4885ABCB11 118/4885LMNA 1627/4885 |
| US-20190224156-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, ADIPOR2, FABP4 | METAP2 1/4885ABCB11 4284/4885LMNA 4501/4885 |
| US-20210299253-A1 | NOVEL AUTOTAC CHIMERIC COMPOUND, AND COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING DISEASES THROUGH TARGETED PROTEIN DEGRADATION COMPRISING THE SAME | ATG7, SQSTM1, CTSA | METAP2 1840/4885ABCB11 2313/4885LMNA 774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.