Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.42 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955809 | 0.88 | HPGDS (0.39) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2E1 | |
| SCHEMBL30741761 | 0.85 | HPGDS (0.50) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2E1 | |
| SCHEMBL6972535 | 0.85 | KDM4C (0.38) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2E1 | |
| SCHEMBL6974237 | 0.84 | CDK5 (0.51) | CYP3A4CYP2D6CYP2C9CYP2C19CYP11B1 | |
| SCHEMBL6952807 | 0.79 | SIGMAR1 (0.45) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2E1 | |
| SCHEMBL6968013 | 0.74 | KDM4C (0.40) | CYP11B1CYP11B2HPGDSKDM5AKDM4C | |
| SCHEMBL6965586 | 0.74 | THRB (0.39) | CYP2A6CYP2B6CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL6972346 | 0.74 | PHF8 (0.38) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2E1 | |
| SCHEMBL28417084 | 0.73 | HPGDS (0.50) | CYP3A4CYP2D6CYP2C9CYP2C19CYP2E1 | |
| SCHEMBL6182324 | 0.72 | LTA4H (0.40) | CYP2C9CYP2C19LTA4HCPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |