Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 17/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799402 | 0.93 | S1PR3 (0.37) | S1PR3ALDH1A1SYK | |
| SCHEMBL8800780 | 0.90 | PTGDR2 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL8800407 | 0.89 | MEN1 (0.33) | S1PR3ALDH1A1KDM4E | |
| SCHEMBL7086183 | 0.86 | TP53 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL7082930 | 0.85 | S1PR3 (0.38) | S1PR3ALDH1A1KDM4ELMNAGFER | |
| SCHEMBL8800346 | 0.84 | MEN1 (0.32) | LMNA | |
| SCHEMBL6973461 | 0.84 | S1PR3 (0.39) | S1PR3ALDH1A1KDM4ELMNAGFER | |
| SCHEMBL8800166 | 0.83 | GRIN1 (0.37) | S1PR3 | |
| SCHEMBL8800655 | 0.83 | CFTR (0.41) | S1PR3ALDH1A1KDM4ELMNA | |
| SCHEMBL6974419 | 0.83 | ALDH1A1 (0.31) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |