Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | GPR39 | O43194 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28281419 | 0.97 | PGR (0.44) | SDHBHTTALDH1A1LOXL2LMNA | |
| SCHEMBL27272061 | 0.84 | HTT (0.38) | HTTALDH1A1LOXL2LMNASMN1; SMN2 | |
| SCHEMBL8669831 | 0.80 | ALDH1A1 (0.53) | SDHBALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL3543675 | 0.78 | ALKBH1 (0.44) | SMN1; SMN2CYP3A4MAPTEGFRBRAF | |
| SCHEMBL4361885 | 0.78 | NR4A1 (0.43) | LMNASMN1; SMN2KDRMET | |
| SCHEMBL7270618 | 0.78 | SMN1; SMN2 (0.60) | ALDH1A1LOXL2LMNASMN1; SMN2LOX | |
| SCHEMBL29126607 | 0.77 | LMNA (0.47) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL11236152 | 0.76 | LMNA (0.46) | SDHBHTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8667528 | 0.76 | MAPT (0.56) | SDHBHTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12042917 | 0.75 | KCNH2 (0.53) | ALDH1A1SMN1; SMN2KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
| EP-0862560-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997019065-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |
| US-5468747-A | Fungicidal compositions and methods of use employing pyrimidine derivatives | ZENECA LIMITED (GB) | 1995-11-21 | — | — | US | disclosed |
| US-5395837-A | Fungicides | ZENECA LIMITED (GB) | 1995-03-07 | — | — | US | disclosed |
| EP-0382375-B1 | Fungicides | ZENECA LTD (GB) | 1994-03-23 | — | — | EP | disclosed |
| US-5264440-A | Pyrimidinyl ether on methyl acrylate substituted phenyl groups | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-23 | — | — | US | disclosed |
| US-5145856-A | Fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-08 | — | — | US | disclosed |
| EP-0382375-A2 | Fungicides | ZENECA LIMITED (GB) | 1990-08-16 | — | — | EP | disclosed |