Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221063 | 0.86 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6217940 | 0.84 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL28718374 | 0.84 | CHRNA7 (0.55) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL8844306 | 0.81 | DRD2 (0.53) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL460139 | 0.80 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL17198006 | 0.80 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| Levodropropizine SCHEMBL29043 | 0.79 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| Dropropizine SCHEMBL8379428 | 0.79 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL7424307 | 0.79 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| Dropropizine SCHEMBL93975 | 0.79 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946538-B1 | INDANE OR DIHYDROINDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2003-08-06 | — | — | EP | disclosed |
| US-6436940-B1 | — | — | 2002-08-20 | — | — | US | disclosed |
| US-6436940-B2 | COMBINED EFFECTS OF DOPAMINE D4 RECEPTOR LIGANDS AND SEROTONIN REUPTAKE INHIBITORS; SCHIZOPHRENIA; ANTIDEPRESSANT; ANXIOLYTIC AGENTS; PSYCHOLOGICAL DISORDERS; PANIC, SLEEP AND OBSESSIVE COMPULSIVE DISORDERS; ANTIISCHEMIC AGENTS | H. LUNDBECK A/S (DK) | 2002-08-20 | — | — | US | disclosed |
| US-6331544-B1 | TREATING POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA AND OTHER PSYCHOSES | H. LUNDBECK A/S (DK) | 2001-12-18 | — | — | US | disclosed |
| US-20010051625-A1 | Indane or dihydroindole derivatives | H. LUNDBECK A/S (DK) | 2001-12-13 | — | — | US | disclosed |
| EP-0946538-A1 | INDANE OR DIHYDROINDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028290-A1 | INDANE OR DIHYDROINDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 1998-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051625-A1 | Indane or dihydroindole derivatives | DRD2, SLC6A3, DRD1 | ADRA2A 113/4885ADRA2B 104/4885ADRA2C 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.