Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 4/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971808 | 0.95 | HTR7 (0.40) | CACNA1COPRK1CACNA1FDRD1DRD4 | |
| SCHEMBL6980780 | 0.91 | CACNA2D1 (0.43) | CACNA1BCACNA1CCACNA2D1CACNB1 | |
| SCHEMBL6977655 | 0.87 | TSHR (0.47) | — | |
| SCHEMBL6975992 | 0.86 | TSHR (0.44) | — | |
| SCHEMBL6974100 | 0.85 | NPC1 (0.48) | CACNA1COPRK1CACNA1FDRD1DRD4 | |
| Hydrochloric Acid SCHEMBL6984860 | 0.85 | OPRL1 (0.37) | OPRK1OPRM1 | |
| SCHEMBL6976114 | 0.83 | USP2 (0.32) | ADRA1DHTR2CHRH1OPRM1DRD3 | |
| Hydrochloric Acid SCHEMBL6982801 | 0.83 | SIGMAR1 (0.41) | OPRK1DRD1DRD4DRD5HRH2 | |
| Hydrochloric Acid SCHEMBL6978285 | 0.82 | SIGMAR1 (0.42) | CACNA1B | |
| SCHEMBL9698183 | 0.81 | OPRM1 (0.38) | OPRK1DRD1ADRA1DHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |