Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5841722 | 0.99 | ALDH1A1 (0.59) | ALDH1A1POLBKMT2ACACNA1GTP53 | |
| SCHEMBL6983602 | 0.90 | SIGMAR1 (0.47) | ALDH1A1CACNA1GMCHR1 | |
| SCHEMBL5840932 | 0.88 | CACNA1G (0.60) | CACNA1GTP53 | |
| SCHEMBL6978967 | 0.87 | LMNA (0.53) | ALDH1A1POLBKMT2ACACNA1GTP53 | |
| SCHEMBL5842521 | 0.87 | SIGMAR1 (0.57) | CACNA1GCCR2KCNH2MCHR1 | |
| Hydrochloric Acid SCHEMBL5842876 | 0.86 | KMT2A (0.55) | ALDH1A1POLBKMT2ACACNA1GTP53 | |
| SCHEMBL6987136 | 0.82 | SIGMAR1 (0.50) | POLBCCR2KCNH2MCHR1 | |
| SCHEMBL6987296 | 0.81 | ALDH1A1 (0.54) | ALDH1A1CACNA1GMCHR1 | |
| SCHEMBL6981732 | 0.81 | MEN1 (0.54) | ALDH1A1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL5842025 | 0.81 | SIGMAR1 (0.49) | POLBCCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |