Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 3/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977704 | 0.89 | HTR7 (0.40) | MC4RHTR7DRD3KCNH2ADRA1B | |
| SCHEMBL6982527 | 0.88 | NPC1 (0.41) | ADRA1BGAARAB9AKMT2A | |
| SCHEMBL4875623 | 0.79 | HTR2A (0.39) | HTR7DRD3UBE2MDCUN1D1ELANE | |
| SCHEMBL6985684 | 0.77 | ADRA1B (0.47) | MC4RADRA1B | |
| SCHEMBL4870508 | 0.77 | HTR2A (0.40) | HTR7DRD3ELANEGAAKMT2A | |
| SCHEMBL6983282 | 0.77 | LMNA (0.45) | ADRA1BRAB9AKMT2A | |
| SCHEMBL6987894 | 0.77 | ADRA1B (0.37) | ADRA1BKMT2A | |
| SCHEMBL6983790 | 0.76 | KMT2A (0.39) | ADRA1BKMT2A | |
| SCHEMBL6983291 | 0.76 | ADRA1B (0.32) | ADRA1B | |
| SCHEMBL6979847 | 0.76 | ADRA1B (0.41) | ADRA1BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |