Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986741 | 0.80 | MTNR1A (0.44) | LMNAMEN1KMT2ATSHRHSD17B10 | |
| SCHEMBL6982527 | 0.79 | NPC1 (0.41) | MEN1KMT2AADRA1BADRA1ANPC1 | |
| SCHEMBL6986641 | 0.78 | EPHX2 (0.38) | TSHRL3MBTL1 | |
| SCHEMBL4866667 | 0.77 | LMNA (0.45) | LMNAPOLBMEN1KMT2ATSHR | |
| SCHEMBL6983872 | 0.77 | MC4R (0.42) | KMT2AADRA1BRAB9A | |
| SCHEMBL6985684 | 0.74 | ADRA1B (0.47) | ADRA1BADRA1AL3MBTL1 | |
| SCHEMBL6983790 | 0.73 | KMT2A (0.39) | POLBMEN1KMT2ACYP2D6ADRA1B | |
| SCHEMBL6979847 | 0.73 | ADRA1B (0.41) | LMNAPOLBKMT2ATSHRADRA1B | |
| SCHEMBL6986746 | 0.72 | SMN1; SMN2 (0.41) | POLBMEN1KMT2ANPC1L3MBTL1 | |
| SCHEMBL6984357 | 0.71 | ALDH1A1 (0.43) | POLBMEN1KMT2ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |