Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PER2 | O15055 | 2/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983872 | 0.88 | MC4R (0.42) | RAB9AADRA1BGAAKMT2A | |
| SCHEMBL6985684 | 0.79 | ADRA1B (0.47) | ADRA1BADRA1A | |
| SCHEMBL6983282 | 0.79 | LMNA (0.45) | NPC1RAB9AADRA1BADRA1AMEN1 | |
| SCHEMBL6987894 | 0.79 | ADRA1B (0.37) | ADRA1BALDH1A1KMT2A | |
| SCHEMBL6983790 | 0.78 | KMT2A (0.39) | ADRA1BADRA1AALDH1A1MALT1MEN1 | |
| SCHEMBL6983291 | 0.78 | ADRA1B (0.32) | ADRA1BADRA1AMALT1SMN1; SMN2 | |
| SCHEMBL6979847 | 0.78 | ADRA1B (0.41) | ADRA1BALDH1A1KMT2A | |
| SCHEMBL6985492 | 0.78 | POLB (0.38) | ADRA1BADRA1AALDH1A1KMT2A | |
| SCHEMBL4871569 | 0.78 | RAB9A (0.41) | NPC1RAB9AADRA1BADRA1APER2 | |
| SCHEMBL6977704 | 0.76 | HTR7 (0.40) | RAB9AADRA1BGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |