Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | RPA1 | P27694 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.30 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984657 | 0.85 | GRM5 (0.35) | HSD11B1ALDH1A1GAAPOLBMDM2 | |
| SCHEMBL6986371 | 0.79 | ALDH1A1 (0.41) | HSD11B1ALDH1A1GAAGRNSORT1 | |
| SCHEMBL6987355 | 0.76 | ALDH1A1 (0.38) | ALDH1A1GAATP53MDM2MCL1 | |
| SCHEMBL6986812 | 0.74 | ALDH1A1 (0.40) | ALDH1A1GAAMDM2MCL1TSHR | |
| SCHEMBL6985846 | 0.73 | BCL2 (0.41) | ALDH1A1GAAMDM2MCL1TSHR | |
| SCHEMBL6985626 | 0.73 | SLC5A1 (0.43) | TP53TSHR | |
| SCHEMBL6982469 | 0.73 | CYP2C9 (0.39) | ALDH1A1GAAMDM2MCL1TSHR | |
| SCHEMBL6985081 | 0.72 | SLC5A1 (0.42) | ALDH1A1POLBTP53 | |
| SCHEMBL6987183 | 0.72 | TSHR (0.45) | ALDH1A1MDM2MCL1TSHRBCL2 | |
| SCHEMBL6981026 | 0.72 | AGTR2 (0.40) | HSD11B1ALDH1A1TP53TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |