Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29113876 | 0.86 | DHFR (0.44) | THRBGABRA1GABRB2DHFRALOX5 | |
| SCHEMBL27427348 | 0.78 | CYP3A4 (0.39) | THRBALDH1A1CYP3A4ALOX5 | |
| SCHEMBL9800893 | 0.78 | GABRA1 (0.38) | ALDH1A1GABRA1GABRB2CA1CA2 | |
| SCHEMBL27679370 | 0.78 | ALOX5 (0.40) | ALDH1A1CYP3A4ALOX5KDM4EGLA | |
| SCHEMBL25189805 | 0.78 | PRKCI (0.56) | THRBALDH1A1CYP3A4KDM4EGLA | |
| SCHEMBL14758383 | 0.77 | ACLY (0.38) | ALDH1A1CYP3A4ALOX5KDM4EGLA | |
| SCHEMBL27440129 | 0.76 | HPGD (0.43) | THRBALDH1A1CYP3A4ALOX5KDM4E | |
| SCHEMBL9140368 | 0.76 | KDM4E (0.40) | ALDH1A1CYP3A4DHFRALOX5KDM4E | |
| SCHEMBL9800890 | 0.76 | THRB (0.54) | THRBALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL93999 | 0.73 | THRB (1.00) | THRBALDH1A1CYP3A4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339680-A1 | SUBSTITUTED OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002020479-A1 | SUBSTITUTED OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-03-14 | — | — | WO | disclosed |