Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 5/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987467 | 0.91 | CYP26A1 (0.36) | CYP26A1TBXAS1FNTAFNTBPGGT1B | |
| SCHEMBL6988039 | 0.90 | CYP26A1 (0.36) | CYP26A1TBXAS1FNTAFNTBPGGT1B | |
| SCHEMBL6981901 | 0.87 | HRH4 (0.39) | CYP26A1TBXAS1FNTAFNTBPGGT1B | |
| SCHEMBL7818934 | 0.80 | CTSS (0.37) | FNTAFNTBPGGT1BCTSSCTSK | |
| SCHEMBL7808546 | 0.79 | CTSS (0.36) | FNTAFNTBPGGT1BCTSSCTSK | |
| SCHEMBL6987186 | 0.77 | TBXAS1 (0.37) | TBXAS1KMT2A | |
| SCHEMBL7816001 | 0.76 | CTSK (0.41) | CTSSCTSKNPSR1 | |
| SCHEMBL6985861 | 0.72 | HMOX2 (0.35) | TBXAS1NPSR1 | |
| SCHEMBL7836648 | 0.71 | MAPT (0.40) | CTSSCTSKMAPTKMT2AMEN1 | |
| SCHEMBL7955112 | 0.71 | MAPT (0.40) | CTSSCTSKMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |