Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818934 | 0.94 | CTSS (0.37) | CTSSCTSKHMOX2KDM4EHRH4 | |
| SCHEMBL7816001 | 0.90 | CTSK (0.41) | CTSSCTSKKDM4EHRH4AHR | |
| SCHEMBL6988039 | 0.89 | CYP26A1 (0.36) | HMOX2HRH4MMP2MMP9MMP8 | |
| SCHEMBL6987186 | 0.88 | TBXAS1 (0.37) | HMOX2HRH4MMP2MMP9MMP8 | |
| SCHEMBL6987467 | 0.83 | CYP26A1 (0.36) | HMOX2FNTAFNTBPGGT1B | |
| SCHEMBL7816193 | 0.82 | CTSS (0.35) | CTSSCTSKHMOX2MMP8 | |
| SCHEMBL6982695 | 0.81 | CTSS (0.33) | CTSSCTSKHMOX2MMP8 | |
| SCHEMBL6985861 | 0.81 | HMOX2 (0.35) | HMOX2KDM4EHRH4MMP2MMP9 | |
| SCHEMBL6981901 | 0.79 | HRH4 (0.39) | CTSSCTSKHRH4FNTAFNTB | |
| SCHEMBL6986413 | 0.79 | CYP26A1 (0.37) | CTSSCTSKNPSR1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |