Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987467 | 0.94 | CYP26A1 (0.36) | CYP26A1TBXAS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6981901 | 0.90 | HRH4 (0.39) | CYP26A1TBXAS1CYP19A1FNTAFNTB | |
| SCHEMBL6986413 | 0.90 | CYP26A1 (0.37) | CYP26A1TBXAS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7808546 | 0.89 | CTSS (0.36) | MMP2MMP9MMP8ADAM17HMOX2 | |
| SCHEMBL6987186 | 0.86 | TBXAS1 (0.37) | TBXAS1MMP2MMP9MMP8ADAM17 | |
| SCHEMBL7818934 | 0.83 | CTSS (0.37) | CYP3A4CYP2D6HMOX2FNTAFNTB | |
| SCHEMBL7816193 | 0.80 | CTSS (0.35) | MMP8HMOX2 | |
| SCHEMBL6982695 | 0.79 | CTSS (0.33) | MMP8HMOX2 | |
| SCHEMBL6985861 | 0.79 | HMOX2 (0.35) | TBXAS1MMP2MMP9MMP8ADAM17 | |
| SCHEMBL7816001 | 0.79 | CTSK (0.41) | CYP19A1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |