Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | WNT3 | P56703 | 1/20 | 0.34 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.34 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808546 | 0.88 | CTSS (0.36) | ADAM17HRH4HMOX2MMP1MMP2 | |
| SCHEMBL6988039 | 0.86 | CYP26A1 (0.36) | TBXAS1ADAM17HRH4HMOX2MMP2 | |
| SCHEMBL7818934 | 0.82 | CTSS (0.37) | HRH4HMOX2 | |
| SCHEMBL6987467 | 0.81 | CYP26A1 (0.36) | TBXAS1AGTR2HMOX2 | |
| SCHEMBL7816193 | 0.80 | CTSS (0.35) | HMOX2MMP8 | |
| SCHEMBL6982695 | 0.79 | CTSS (0.33) | AGTR2HMOX2ALDH1A1MMP8 | |
| SCHEMBL6985861 | 0.79 | HMOX2 (0.35) | TBXAS1ADAM17HRH4HMOX2MMP2 | |
| SCHEMBL7816001 | 0.79 | CTSK (0.41) | HRH4 | |
| SCHEMBL6981901 | 0.77 | HRH4 (0.39) | TBXAS1AGTR2HRH4 | |
| SCHEMBL6980731 | 0.77 | AGTR2 (0.34) | AGTR2ALDH1A1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |