Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986746 | 0.83 | SMN1; SMN2 (0.41) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL6984357 | 0.82 | ALDH1A1 (0.43) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL6986641 | 0.81 | EPHX2 (0.38) | ALDH1A1TSHRNPSR1 | |
| SCHEMBL6983282 | 0.80 | LMNA (0.45) | MEN1KMT2ANPC1LMNATSHR | |
| SCHEMBL4875374 | 0.78 | MTNR1A (0.45) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL6980148 | 0.77 | SMN1; SMN2 (0.43) | MEN1KMT2AALDH1A1NPC1RECQL | |
| SCHEMBL6981458 | 0.77 | SMN1; SMN2 (0.43) | MEN1KMT2AALDH1A1NPC1RECQL | |
| SCHEMBL6983790 | 0.74 | KMT2A (0.39) | MEN1KMT2AALDH1A1CYP2C9KDM4E | |
| SCHEMBL6982527 | 0.74 | NPC1 (0.41) | MEN1KMT2AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL7135238 | 0.73 | ADRA1B (0.44) | MEN1KMT2AALDH1A1RECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |