Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816193 | 0.90 | CTSS (0.35) | CTSSCTSKANPEPMMP8HMOX2 | |
| SCHEMBL6980731 | 0.82 | AGTR2 (0.34) | CTSSCTSKAGTR2ALDH1A1MMP8 | |
| SCHEMBL7808546 | 0.81 | CTSS (0.36) | CTSSCTSKMMP8HMOX2 | |
| SCHEMBL6988039 | 0.79 | CYP26A1 (0.36) | MMP8HMOX2 | |
| SCHEMBL6987186 | 0.79 | TBXAS1 (0.37) | AGTR2ALDH1A1MMP8HMOX2 | |
| SCHEMBL6986290 | 0.77 | CYP19A1 (0.34) | CTSSCTSKAGTR2 | |
| SCHEMBL6982283 | 0.77 | REN (0.36) | CTSSCTSK | |
| SCHEMBL6985861 | 0.77 | HMOX2 (0.35) | MMP8HMOX2 | |
| SCHEMBL6984090 | 0.76 | AGTR2 (0.32) | AGTR2MMP8 | |
| SCHEMBL7818934 | 0.75 | CTSS (0.37) | CTSSCTSKHMOX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |