Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036048 | 0.76 | SMN1; SMN2 (0.41) | GPR3MAPTNPSR1CA12CA9 | |
| SCHEMBL7035643 | 0.76 | GPR3 (0.39) | GPR3ALKBH5FTOKDM4EMAPT | |
| SCHEMBL4014784 | 0.72 | ALDH1A1 (0.35) | GPR3KDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL7838631 | 0.72 | GPR3 (0.37) | GPR3KDM4EMAPTCA12CA9 | |
| SCHEMBL323754 | 0.72 | ALDH1A1 (0.41) | KDM4EMAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2203714 | 0.72 | KDM4E (0.43) | KDM4EMAPTALDH1A1GAACYP2C19 | |
| SCHEMBL11634743 | 0.71 | IMPDH2 (0.32) | KDM4EALDH1A1 | |
| SCHEMBL3390922 | 0.70 | CYP11B2 (0.35) | MAPTALDH1A1SMN1; SMN2RXFP1KMT2A | |
| SCHEMBL11634748 | 0.69 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2GLAGAA | |
| SCHEMBL11161798 | 0.69 | TLR8 (0.47) | KDM4EMAPTALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112457298-B | Substituted 2-anilinopyrimidine derivatives and their use as epidermal growth factor receptor modulators | 贝达医药公司 | 2024-05-07 | — | — | CN | claimed |
| CN-112375067-B | Substituted 2-anilinopyrimidine derivatives and their use as epidermal growth factor receptor modulators | 贝达医药公司 | 2024-03-15 | — | — | CN | claimed |
| CN-114430681-A | Treatment of EGFR mutation-related cancers with combinations of EGFR and CDK4/6 inhibitors | 贝达医药公司 | 2022-05-03 | — | — | CN | claimed |
| WO-2021061695-A1 | TREATMENT OF EGFR MUTANT-RELATED CANCERS USING A COMBINATION OF EGFR AND CDK4/6 INHIBITORS | BETA PHARMA, INC. (US) | 2021-04-01 | — | — | WO | claimed |
| CN-112457298-A | Substituted 2-anilinopyrimidine derivatives and their use as epidermal growth factor receptor modulators | 贝达医药公司 | 2021-03-09 | — | — | CN | claimed |
| CN-112375067-A | Substituted 2-anilinopyrimidine derivatives and their use as epidermal growth factor receptor modulators | 贝达医药公司 | 2021-02-19 | — | — | CN | claimed |
| CN-108024993-B | Substituted 2-anilinopyrimidine derivatives and their use as epidermal growth factor receptor modulators | 贝达医药公司 | 2020-11-06 | — | — | CN | claimed |
| US-20200216421-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | BETA PHARMA, INC. (US) | 2020-07-09 | — | — | US | claimed |
| US-10590111-B2 | Substituted 2-anilinopyrimidine derivatives as EGFR modulators | BETA PHARMA, INC. (US) | 2020-03-17 | — | — | US | claimed |
| US-20170362203-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | BETA PHARMA, INC. (US) | 2017-12-21 | — | — | US | claimed |
| CN-102459166-A | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV | 2012-05-16 | — | — | CN | claimed |
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| US-20100324012-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-23 | — | — | US | claimed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |
| CN-1178933-C | Photochromic diarylheterocycloethylene compounds sensitive to blue light and its preparing process and usage | 中国科学院感光化学研究所 | 2004-12-08 | — | — | CN | claimed |
| US-4870087-A | Indole containing, 2-thienyl-1,2,3,6-tetrahydropyridyls and their pharmaceutical use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-09-26 | — | — | US | claimed |
| US-4617309-A | Sulfur-containing indole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-14 | — | — | US | claimed |
| US-4132436-A | Recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1979-01-02 | — | — | US | claimed |
| US-4119777-A | BY OXIDATION OF A THIOAMIDE DERIVATIVE | FUJI PHOTO FILM CO., LTD. (JP) | 1978-10-10 | — | — | US | claimed |
| US-4054718-A | Heat-sensitive recording material containing a malachite green color former | CIBA-GEIGY CORPORATION (US) | 1977-10-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590111-B2 | Substituted 2-anilinopyrimidine derivatives as EGFR modulators | EGFR, ERBB2, ERBB4 | GPR3 424/4885ALKBH5 2563/4885FTO 4384/4885 |
| US-20100324012-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | PNLIP, LPL, LIPA | GPR3 2040/4885ALKBH5 1263/4885FTO 872/4885 |
| US-20200216421-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | EGFR, ERBB2, ERBB4 | GPR3 424/4885ALKBH5 2563/4885FTO 4384/4885 |
| US-20170362203-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | EGFR, ERBB2, ERBB4 | GPR3 424/4885ALKBH5 2563/4885FTO 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.