Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700437 | 0.70 | GPR3 (0.41) | MEN1ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL323754 | 0.65 | ALDH1A1 (0.41) | TP53MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL2203714 | 0.65 | KDM4E (0.43) | MEN1ALDH1A1KMT2AMAPTCYP2D6 | |
| SCHEMBL31469417 | 0.65 | CYP1A2 (0.48) | CYP11B2MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL16103839 | 0.64 | OPRM1 (0.44) | CYP11B2MEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL11693011 | 0.63 | GAA (0.41) | HRH3MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL9673866 | 0.63 | CCR5 (0.60) | CYP11B2RPS6KB1ROCK1TP53MEN1 | |
| SCHEMBL6030724 | 0.62 | HSD17B10 (0.37) | MEN1ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29643238 | 0.61 | ALKBH5 (0.56) | MEN1ALDH1A1KMT2AMAPTC5AR1 | |
| SCHEMBL11634743 | 0.61 | IMPDH2 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |