Sugi Predict

Sugi Predict / Compounds / SCHEMBL70114

SCHEMBL70114

SCHEMBL70114

O=Cc1cnn(-c2ccccc2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 3/20 0.63
▸ RAB9A P51151 3/20 0.63
▸ SMN1; SMN2 Q16637 3/20 0.63
▸ GAA P10253 1/20 0.53
▸ HPGDS O60760 1/20 0.53
▸ ALKBH2 Q6NS38 1/20 0.53
▸ MTOR P42345 2/20 0.52
▸ RPTOR Q8N122 1/20 0.50
▸ MLST8 Q9BVC4 1/20 0.50
▸ P2RX7 Q99572 1/20 0.50
▸ HDAC1 Q13547 1/20 0.48
▸ HDAC2 Q92769 1/20 0.48
▸ ALDH1A1 P00352 9/20 0.46
▸ KMT2A Q03164 5/20 0.46
▸ MEN1 O00255 4/20 0.46
▸ KDM4E B2RXH2 3/20 0.46
▸ MAPT P10636 3/20 0.46
▸ CACNA1B Q00975 1/20 0.46
▸ APBA1 Q02410 1/20 0.46
▸ PTGS2 P35354 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL17731583 0.98 NPC1 (0.61) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL18586055 0.85 NPC1 (0.49) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL27768403 0.83 SMN1; SMN2 (0.45) NPC1RAB9ASMN1; SMN2HPGDSALKBH2
SCHEMBL18586312 0.83 NPC1 (0.47) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL9191311 0.82 NPC1 (0.60) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL6854096 0.82 NPC1 (0.65) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL6854100 0.82 NPC1 (0.65) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL18586422 0.82 MTOR (0.56) NPC1RAB9ASMN1; SMN2MTORRPTOR
SCHEMBL27607655 0.82 HPGDS (0.55) NPC1RAB9ASMN1; SMN2GAAHPGDS
SCHEMBL18586388 0.81 ALDH1A1 (0.53) NPC1RAB9ASMN1; SMN2MTORRPTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12486255-B2 Modulators of RAS GTPase TOSK, INC. (US) 2025-12-02 — — US disclosed
US-12479797-B2 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors Jubilant Epicore LLC (US) 2025-11-25 — — US disclosed
EP-3455204-B1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS Jubilant Epicore LLC (US) 2025-10-29 — — EP disclosed
EP-4626891-A1 FUSED PYRIMIDINES AS MASP-2 INHIBITORS Omeros Corporation (US) 2025-10-08 — — EP disclosed
EP-4605386-A1 ANTI-VIRAL COMPOUNDS Aligos Therapeutics, Inc. (US) 2025-08-27 — — EP disclosed
US-20250195483-A1 SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMA (US) 2025-06-19 — — US disclosed
EP-4476207-A1 SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME Vertex Pharmaceuticals Incorporated (US) 2024-12-18 — — EP disclosed
US-20240279206-A1 Modulators of RAS GTPase TOSK, INC. 2024-08-22 — — US disclosed
US-20240228499-A1 MASP-2 INHIBITORS AND METHODS OF USE OMEROS CORPORATION (US) 2024-07-11 — — US disclosed
US-20240182444-A1 ANTI-VIRAL COMPOUNDS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2024-06-06 — — US disclosed
WO-2002002567-A1 THIENOPYRROLIDINONES F. HOFFMANN-LA ROCHE AG (CH) 2002-01-10 — — WO disclosed
US-5962489-A FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1999-10-05 — — US disclosed
US-5817682-A OXALOXIMES OF PYRAZOLES AND ISOXAZOLES BASF AKTIENGESELLSCHAFT (DE) 1998-10-06 — — US disclosed
US-5736566-A FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-04-07 — — US disclosed
US-5672616-A FUNGICIDE BASF AKTIENGESELLSCHAFT (DE) 1997-09-30 — — US disclosed
US-5663185-A FUNGICIDES, INSECTICIDES, NEMATOCIDES BASF AKTIENGESELLSCHAFT (DE) 1997-09-02 — — US disclosed
EP-0579071-A2 Heteroaromatic compounds and plant-protecting agents containing them BASF Aktiengesellschaft (DE) 1994-01-19 — — EP disclosed
US-4220792-A ANTIDIABETIC AGENTS SANDOZ, INC. (US) 1980-09-02 — — US disclosed
US-4125530-A FROM 1,1-DIHALO-3,3,3-TRIFLUOROACETONE, BASE, AMMONIA AND A CARBOXALDEHYDE MERCK & CO., INC. (US) 1978-11-14 — — US disclosed
US-4032522-A ANTI-GOUT, ANTI-HYPERURICEMIC MERCK & CO., INC. (US) 1977-06-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240228499-A1 MASP-2 INHIBITORS AND METHODS OF USE MASP2, SPINT2, SERPINB1 NPC1 3979/4885RAB9A 2310/4885SMN1; SMN2 3397/4885
US-12486255-B2 Modulators of RAS GTPase KRAS, HRAS, NRAS NPC1 2461/4885RAB9A 61/4885SMN1; SMN2 2677/4885
US-20250195483-A1 SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME APOL1, PNLIP, SAAL1 NPC1 261/4885RAB9A 2829/4885SMN1; SMN2 527/4885
US-20240182444-A1 ANTI-VIRAL COMPOUNDS EIF2AK2, ZC3HAV1, HAVCR2 NPC1 34/4885RAB9A 347/4885SMN1; SMN2 239/4885
US-20240279206-A1 Modulators of RAS GTPase KRAS, HRAS, NRAS NPC1 2461/4885RAB9A 61/4885SMN1; SMN2 2677/4885
US-12479797-B2 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors HDAC1, HDAC11, HDAC2 NPC1 297/4885RAB9A 1828/4885SMN1; SMN2 1068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.