Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.35 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.33 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GLB1 | P16278 | 1/20 | 0.33 |
| ▸ | CHAT | P28329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL11316357 | 0.82 | CNR2 (0.40) | THRBALOX12CNR2 | |
| SCHEMBL7791002 | 0.79 | TTR (0.47) | ALDH1A1ALOX15HSD17B10LDHA | |
| SCHEMBL4642257 | 0.79 | LDHA (0.36) | ALDH1A1TSHRHPGDHSD17B10LDHA | |
| SCHEMBL7020849 | 0.78 | TTR (0.46) | ALDH1A1ALOX15HSD17B10LDHA | |
| SCHEMBL30537735 | 0.77 | GABRA1 (0.43) | ALDH1A1HTTCNR2 | |
| SCHEMBL5682891 | 0.77 | GABRA1 (0.43) | ALDH1A1HTTCNR2 | |
| SCHEMBL14977704 | 0.76 | THRB (0.41) | THRBNR4A1ALDH1A1TSHRCYP3A4 | |
| Potassium Ion SCHEMBL6616004 | 0.75 | KDM4E (0.41) | THRBNR4A1TSHRHPGD | |
| SCHEMBL11195921 | 0.74 | P2RY4 (0.39) | THRBALDH1A1TSHRCYP3A4HPGD | |
| SCHEMBL11192937 | 0.73 | CYP1A2 (0.52) | THRBNR4A1ALDH1A1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001064054-A9 | METHOD FOR HARDENING GRANULAR INORGANIC SALT COMPOUNDS | LOBECO PRODUCTS INC (US) | 2003-01-03 | — | — | WO | disclosed |
| US-6365120-B1 | HARDENING USING A NAPHTHALENESULFONATE SALT AND AMMONIUM SULFATE | LOBECO PRODUCTS, INC. | 2002-04-02 | — | — | US | disclosed |
| WO-2001064054-A1 | METHOD FOR HARDENING GRANULAR INORGANIC SALT COMPOUNDS | LOBECO PRODUCTS, INC. (US) | 2001-09-07 | — | — | WO | disclosed |