Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149405 | 0.94 | TPSAB1 (0.36) | LMNATPSAB1SLC2A1 | |
| SCHEMBL4405326 | 0.93 | PDK1 (0.41) | PDK1GAALMNATLR9TLR8 | |
| SCHEMBL7142155 | 0.91 | CHRM2 (0.35) | LMNATPSAB1CCR5SLC2A1 | |
| SCHEMBL7148752 | 0.90 | CCR5 (0.36) | LMNACCR5 | |
| SCHEMBL7148789 | 0.89 | CCR5 (0.36) | TPSAB1CCR5SLC2A1 | |
| SCHEMBL7148965 | 0.86 | RORC (0.33) | LMNATLR9TLR8TLR7TPSAB1 | |
| SCHEMBL7150781 | 0.86 | HTR2A (0.37) | GAALMNA | |
| SCHEMBL4402034 | 0.86 | LMNA (0.47) | PDK1GAALMNATPSAB1AOC3 | |
| SCHEMBL4412034 | 0.86 | LMNA (0.40) | LMNATPSAB1SLC2A1 | |
| SCHEMBL4404630 | 0.84 | LMNA (0.38) | LMNATPSAB1ALDH1A1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |