Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403365 | 0.94 | TP53 (0.36) | TP53GAAPARP10LMNACHRM4 | |
| SCHEMBL7148965 | 0.89 | RORC (0.33) | TP53LMNA | |
| SCHEMBL7149405 | 0.88 | TPSAB1 (0.36) | LMNA | |
| SCHEMBL7024701 | 0.86 | PDK1 (0.38) | GAALMNA | |
| SCHEMBL7142155 | 0.86 | CHRM2 (0.35) | LMNA | |
| SCHEMBL7148789 | 0.85 | CCR5 (0.36) | — | |
| SCHEMBL7148752 | 0.85 | CCR5 (0.36) | LMNA | |
| SCHEMBL4411316 | 0.82 | RORC (0.35) | TP53PARP10LMNA | |
| SCHEMBL4407001 | 0.82 | GAA (0.35) | TP53GAAPARP10LMNA | |
| SCHEMBL4412034 | 0.81 | LMNA (0.40) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |